Bernhard Boser


A Real-Time Intraoperative Fluorescence Imager for Microscopic Residual Tumor

No method currently exists to identify small clusters of 100s or 1000s of cancer cells during cancer surgery. A main limiting factor is the traditional optics used in fluorescence imaging cannot be miniaturized to the size necessary to fit inside a tumor cavity. We have developed an imaging strategy that forgoes external optical elements for focusing light and instead uses angle-selective gratings patterned in the metal interconnect of a standard CMOS process. With the optics miniaturized to the chip-scale, only a 15 μm amorphous silicon optical wavelength filter patterned on the chip is...